A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling.

@article{Chen2013ANM,
  title={A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling.},
  author={Yung-Chih Chen and Anh Bui and Jeannine Diesch and Richard Manasseh and Christian Hausding and Jennifer E Rivera and Izhak Haviv and Alex Agrotis and Nay Min Htun and Jeremy Jowett and Christoph E Hagemeyer and Ross D Hannan and Alex Bobik and Karlheinz Peter},
  journal={Circulation research},
  year={2013},
  volume={113 3},
  pages={252-65}
}
RATIONALE The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. OBJECTIVE Development and use of a mouse model of plaque rupture that reflects the end stage of human atherosclerosis. METHODS AND RESULTS On the basis of flow measurements and computational fluid… CONTINUE READING
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