A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation

@inproceedings{Sievert2014ANM,
  title={A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation},
  author={Henning Sievert and Nora P{\"a}llmann and Katharine K. Miller and Irm Hermans-Borgmeyer and Simone Venz and Ataman Sendoel and Michael Preukschas and Michaela Schweizer and Steffen Boettcher and Philipp Christoph Janiesch and Thomas Streichert and R. {\'A}lvarez-Sala Walther and Michael O. Hengartner and Markus G. Manz and Tim Henrik Br{\"u}mmendorf and C Carsten Bokemeyer and Melanie Braig and Joachim Hauber and Kent E. Duncan and Stefan Balabanov},
  booktitle={Disease models & mechanisms},
  year={2014}
}
The central importance of translational control by post-translational modification has spurred major interest in regulatory pathways that control translation. One such pathway uniquely adds hypusine to eukaryotic initiation factor 5A (eIF5A), and thereby affects protein synthesis and, subsequently, cellular proliferation through an unknown mechanism. Using… CONTINUE READING