A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide.

@article{Morrison1999ANM,
  title={A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide.},
  author={Gillian M. Morrison and Donald J Davidson and Julia R. Dorin},
  journal={FEBS letters},
  year={1999},
  volume={442 1},
  pages={112-6}
}
Studies have shown that beta defensins are present in the human airways and may be relevant to the pathogenesis of cystic fibrosis lung disease. Here we report the identification of a novel mouse gene, Defb2, which shows sequence similarity to previously described mouse and human airway beta defensins. Defb2 does not appear to be expressed in the airways of untreated mice but it is upregulated in response to lipopolysaccharide. The induced expression of this gene by an inflammatory stimulus… CONTINUE READING