A novel monoclonal antibody (OPD4) recognizing a helper/inducer T cell subset. Its application to paraffin-embedded tissues.

@article{Yoshino1989ANM,
  title={A novel monoclonal antibody (OPD4) recognizing a helper/inducer T cell subset. Its application to paraffin-embedded tissues.},
  author={Tadashi Yoshino and H Mukuzono and Hiroki Aoki and Kiyoshi Takahashi and Tamotsu Takeuchi and Ichiro Kubonishi and Y. H. Ohtsuki and Makoto Motoi and Tadaatsu Akagi},
  journal={The American journal of pathology},
  year={1989},
  volume={134 6},
  pages={1339-46}
}
A novel monoclonal antibody (MAb), OPD4, reactive with a helper/inducer (H/I) subset of T cells in formalin-fixed, paraffin-embedded tissue sections, has been identified through immunization with an activated H/I T cell line, namely DL40. The antibody is an IgG1 antibody and it recognizes an antigen with a molecular weight of 200 kd, corresponding to that of leukocyte common antigen. OPD4+/CD4+ T cells provided better help for pokeweed mitogen-stimulated polyclonal IgG production than OPD4-/CD4… CONTINUE READING

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