A novel molecule integrating therapeutic and diagnostic activities reveals multiple aspects of stem cell-based therapy.

@article{Hingtgen2010ANM,
  title={A novel molecule integrating therapeutic and diagnostic activities reveals multiple aspects of stem cell-based therapy.},
  author={Shawn D Hingtgen and Randa Kasmieh and Jeroen A J M van de Water and Ralph Weissleder and Khalid Shah},
  journal={Stem cells},
  year={2010},
  volume={28 4},
  pages={832-41}
}
Stem cells are promising therapeutic delivery vehicles; however pre-clinical and clinical applications of stem cell-based therapy would benefit significantly from the ability to simultaneously determine therapeutic efficacy and pharmacokinetics of therapies delivered by engineered stem cells. In this study, we engineered and screened numerous fusion variants that contained therapeutic (TRAIL) and diagnostic (luciferase) domains designed to allow simultaneous investigation of multiple events in… CONTINUE READING

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