A novel molecular pathway for Snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis.

@article{Grant2014ANM,
  title={A novel molecular pathway for Snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis.},
  author={Jeanette L. Grant and Michael C. Fishbein and Long-Sheng Hong and Kostyantyn Krysan and John D. Minna and Jerry W Shay and Tonya C. Walser and Steven Dubinett},
  journal={Cancer prevention research},
  year={2014},
  volume={7 1},
  pages={150-60}
}
Definition of the molecular pathogenesis of lung cancer allows investigators an enhanced understanding of the natural history of the disease, thus fostering development of new prevention strategies. In addition to regulating epithelial-to-mesenchymal transition (EMT), the transcription factor Snail exerts global effects on gene expression. Our recent studies reveal that Snail is upregulated in non-small cell lung cancer (NSCLC), is associated with poor prognosis, and promotes tumor progression… CONTINUE READING
Highly Cited
This paper has 34 citations. REVIEW CITATIONS