A novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neurones.

@article{Smart1992ANM,
  title={A novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neurones.},
  author={Trevor G Smart},
  journal={The Journal of physiology},
  year={1992},
  volume={447},
  pages={
          587-625
        }
}
1. The properties of gamma-aminobutyric acidA (GABAA) receptor-ion channel complexes and the interaction with the transition metal zinc, were studied on rat sympathetic and cerebellar neurones in dissociated culture using patch clamp recording techniques. 2. The antagonism of GABA-induced membrane currents by zinc on sympathetic neurones was subject to developmental influence. Using embryonic sympathetic neurones acutely cultured for 24-72 h, GABA responses were more depressed by zinc when… CONTINUE READING
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