A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11.

@article{Mohlke1996ANM,
  title={A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11.},
  author={Karen L. Mohlke and William C. Nichols and Randal J. Westrick and Edward K. Novak and Kathleen A Cooney and Richard T. Swank and David Ginsburg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 26},
  pages={15352-7}
}
Type 1 von Willebrand disease (VWD), characterized by reduced levels of plasma von Willebrand factor (VWF), is the most common inherited bleeding disorder in humans. Penetrance of VWD is incomplete, and expression of the bleeding phenotype is highly variable. In addition, plasma VWF levels vary widely among normal individuals. To identify genes that influence VWF level, we analyzed a genetic cross between RIIIS/J and CASA/Rk, two strains of mice that exhibit a 20-fold difference in plasma VWF… CONTINUE READING