A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis

@article{Wang2003ANM,
  title={A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis},
  author={Bailiang Wang and Daoyan Wei and Vanessa E Crum and Erica L. Richardson and Henry H Xiong and Yu Luo and Suyun Huang and James L Abbruzzese and Keping Xie},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={1771-1782}
}
In the present study, a model system for studying the role of nitric oxide (NO) in tumor growth and metastasis was reported. Incubation of Panc02 murine pancreatic adenocarcinoma cells in vitro with cytokines and interferon led to heterogeneous expression of NO synthase II (NOS II) protein. Clonal sublines expressing different levels of NOS II were then established using a limited dilution technique. After orthotopical implantation into the pancreas of syngeneic C57BL/6 mice, clones with a low… CONTINUE READING

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