A novel model of invasive fungal rhinosinusitis in rats.


BACKGROUND Invasive fungal rhinosinusitis (IFRS) is a life-threatening inflammatory disease that affects immunocompromised patients, but animal models of the disease are scarce. This study aimed to develop an IFRS model in neutropenic rats. METHODS The model was established in three consecutive steps: unilateral nasal obstruction with Merocel sponges… (More)
DOI: 10.2500/ajra.2013.27.3953


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