A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.

@article{Lu2007ANM,
  title={A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.},
  author={Chuang Lu and Gerald T. Miwa and Shimoga R. Prakash and L Gan and Suresh K. Balani},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2007},
  volume={35 1},
  pages={79-85}
}
Ketoconazole has generally been used as a standard inhibitor for studying clinical pharmacokinetic drug-drug interactions (DDIs) of drugs that are primarily metabolized by CYP3A4/5. However, ketoconazole at therapeutic, high concentrations also inhibits cytochromes P450 (P450) other than CYP3A4/5, which has made the predictions of DDIs less accurate. Determining the in vivo inhibitor concentration at the enzymatic site is critical for predicting the clinical DDI, but it remains a technical… CONTINUE READING

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