A novel mode of regulation of the Staphylococcus aureus catabolite control protein A (CcpA) mediated by Stk1 protein phosphorylation.

@article{Leiba2012ANM,
  title={A novel mode of regulation of the Staphylococcus aureus catabolite control protein A (CcpA) mediated by Stk1 protein phosphorylation.},
  author={Jade Leiba and Torsten Hartmann and Marie-Eve Cluzel and Martin Cohen-Gonsaud and Fr{\'e}d{\'e}ric Delolme and Markus Bischoff and Virginie Molle},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 52},
  pages={43607-19}
}
The Staphylococcus aureus serine/threonine protein kinase Stk1 (also known as PknB) affects different key pathways such as cell wall metabolism, antibiotic susceptibility, and regulation of virulence. Here we report that the catabolite control protein A (CcpA), a highly conserved regulator of carbon catabolite repression and virulence in a number of gram-positive pathogens, was efficiently phosphorylated in vitro and in vivo by Stk1 in S. aureus, whereas the CcpA homologues of Bacillus subtilis… CONTINUE READING

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