A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines.

@article{Matsuguchi2001ANM,
  title={A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines.},
  author={Tetsuya Matsuguchi and Tipayaratn Musikacharoen and Thomas R. Johnson and Andrew S. Kraft and Yasunobu Yoshikai},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 20},
  pages={6999-7009}
}
We have isolated a cDNA homologous to known dual-specificity phosphatases from a mouse macrophage cDNA library and termed it MKP-M (for mitogen-activated protein kinase phosphatase isolated from macrophages). Three other presumed splice variant isoforms have also been identified for MKP-M. The longest and most abundant mRNA contains an open reading frame corresponding to 677 amino acids and produces an 80-kDa protein. The deduced amino acid sequence of MKP-M is most similar to those of hVH-5… CONTINUE READING
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