A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.

@article{Nez2012ANM,
  title={A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.},
  author={Luz Elena N{\'u}{\~n}ez and Stephen Eric Nybo and Javier Gonz{\'a}lez-Sab{\'i}n and Maria de Jesus Diaz Perez and Nuria Men{\'e}ndez and Alfredo F. Bra{\~n}a and Khaled A. Shaaban and Min He and Francisco Mor{\'i}s and Jos{\'e} A Salas and J. 0. Taylor Rohr and Carmen M{\'e}ndez},
  journal={Journal of medicinal chemistry},
  year={2012},
  volume={55 12},
  pages={5813-25}
}
Mithramycin is an antitumor compound produced by Streptomyces argillaceus that has been used for the treatment of several types of tumors and hypercalcaemia processes. However, its use in humans has been limited because of its side effects. Using combinatorial biosynthesis approaches, we have generated seven new mithramycin derivatives, which differ from the parental compound in the sugar profile or in both the sugar profile and the 3-side chain. From these studies three novel derivatives were… CONTINUE READING

From This Paper

Topics from this paper.
18 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…