A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia.

@article{Charfeddine2003ANM,
  title={A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia.},
  author={Ch{\'e}rine Charfeddine and Mourad Mokni and R Ben Mousli and Reyhan Elkares and Chiraz Souissi Bouchlaka and Samir Boubaker and S Ghedamsi and Dorra Baccouche and Amel Ben Osman and Koussay Dellagi and Sonia Abdelhak},
  journal={The British journal of dermatology},
  year={2003},
  volume={149 6},
  pages={1108-15}
}
BACKGROUND Mal de Meleda (MDM) is a rare autosomal recessive skin disorder which belongs to the clinically and genetically heterogeneous group of palmoplantar keratodermas (PPK). Clinically, MDM is characterized by erythema and hyperkeratosis of the palms and soles with sharp demarcation that appears soon after birth and progressively extends to the dorsal surface of the hands and feet. OBJECTIVES Except for the molecular study reported in Algerian families, MDM has not yet been investigated… CONTINUE READING

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