A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents.

Abstract

A novel, simple, and efficient method for the synthesis of 4,5-dihydropyrazole derivatives has been developed. The reaction proceeded through the base-induced isomerization of easily accessible propargyl alcohols followed by cyclization of α,β-unsaturated hydrazones. Furthermore, selected compounds 3ab and 3ac exhibited good activities against Bel-7404 (human hepatoma cancer), HepG2 (human liver cancer), NCI-H460 (human lung cancer) and SKOV3 (human ovarian cancer) cell lines with IC50 in the range of 22-46 μmol L(-1).

DOI: 10.1039/c3ob42432d

Cite this paper

@article{Wang2014ANM, title={A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents.}, author={Xu Wang and Ying-Ming Pan and Xiao-chao Huang and Zhong-Yuan Mao and Hengshan Wang}, journal={Organic & biomolecular chemistry}, year={2014}, volume={12 13}, pages={2028-32} }