A novel method to identify hub pathways of rheumatoid arthritis based on differential pathway networks

@article{Wei2017ANM,
  title={A novel method to identify hub pathways of rheumatoid arthritis based on differential pathway networks},
  author={Shitong Wei and Y. Sun and Shi Zong},
  journal={Molecular Medicine Reports},
  year={2017},
  volume={16},
  pages={3187 - 3193}
}
The aim of the current study was to identify hub pathways of rheumatoid arthritis (RA) using a novel method based on differential pathway network (DPN) analysis. The present study proposed a DPN where protein-protein interaction (PPI) network was integrated with pathway-pathway interactions. Pathway data was obtained from background PPI network and the Reactome pathway database. Subsequently, pathway interactions were extracted from the pathway data by building randomized gene-gene interactions… Expand
2 Citations

References

SHOWING 1-10 OF 41 REFERENCES
Reactome: a database of reactions, pathways and biological processes
  • 1,237
  • PDF
A Network-Based Method to Assess the Statistical Significance of Mild Co-Regulation Effects
  • 20
  • PDF
Detecting protein complexes in a PPI network: a gene ontology based multi-objective evolutionary approach.
  • 42
  • PDF
A survey of computational methods for protein complex prediction from protein interaction networks
  • 91
  • PDF
Protein–protein interaction networks and subnetworks in the biology of disease
  • 66
  • PDF
Personalized identification of altered pathways in cancer using accumulated normal tissue data
  • 78
  • PDF
Extracting a few functionally reproducible biomarkers to build robust subnetwork-based classifiers for the diagnosis of cancer.
  • 17
Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges
  • 1,122
  • PDF
Detecting overlapping protein complexes in protein-protein interaction networks
  • 865
  • Highly Influential
  • PDF
...
1
2
3
4
5
...