A novel method to identify gene–gene effects in nuclear families: the MDR‐PDT

  title={A novel method to identify gene–gene effects in nuclear families: the MDR‐PDT},
  author={Eden R. Martin and Marylyn DeRiggi Ritchie and Lance W. Hahn and S. Kang and J. H. Moore},
  journal={Genetic Epidemiology},
It is now well recognized that gene–gene and gene–environment interactions are important in complex diseases, and statistical methods to detect interactions are becoming widespread. Traditional parametric approaches are limited in their ability to detect high‐order interactions and handle sparse data, and standard stepwise procedures may miss interactions that occur in the absence of detectable main effects. To address these limitations, the multifactor dimensionality reduction (MDR) method… 
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Multifactor-dimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus
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Multilocus Analysis of Hypertension: A Hierarchical Approach
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Computational analysis of gene-gene interactions using multifactor dimensionality reduction
  • J. Moore
  • Biology
    Expert review of molecular diagnostics
  • 2004
A novel strategy known as multifactor dimensionality reduction that was specifically designed for the identification of multilocus genetic effects is presented and several case studies that demonstrate the detection of gene–gene interactions in common diseases such as atrial fibrillation, Type II diabetes and essential hypertension are discussed.