A novel method to identify gene–gene effects in nuclear families: the MDR‐PDT

@article{Martin2006ANM,
  title={A novel method to identify gene–gene effects in nuclear families: the MDR‐PDT},
  author={Eden R. Martin and Marylyn DeRiggi Ritchie and Lance W. Hahn and S. Kang and J. H. Moore},
  journal={Genetic Epidemiology},
  year={2006},
  volume={30}
}
It is now well recognized that gene–gene and gene–environment interactions are important in complex diseases, and statistical methods to detect interactions are becoming widespread. Traditional parametric approaches are limited in their ability to detect high‐order interactions and handle sparse data, and standard stepwise procedures may miss interactions that occur in the absence of detectable main effects. To address these limitations, the multifactor dimensionality reduction (MDR) method… 
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