A novel method for the prediction of functional biological activity of polyethylene wear debris.

@article{Fisher2001ANM,
  title={A novel method for the prediction of functional biological activity of polyethylene wear debris.},
  author={J. Berton Fisher and Judith A. Bell and P S Barbour and Joanne L. Tipper and Jane Bridget Matthews and A. A. Besong and Martin H. Stone and Eileen Ingham},
  journal={Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine},
  year={2001},
  volume={215 2},
  pages={
          127-32
        }
}
The comparative performance of artificial hip joints has been extensively investigated in vitro through measurements of wear volumes. In vivo a major cause of long-term failure is wear-debris-induced osteolysis. These adverse biological reactions are not simply dependent on wear volume, but are also controlled by the size and volumetric concentration of the debris. A novel model is presented which predicts functional biological activity; this is determined by integrating the product of the… CONTINUE READING

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