A novel method for rapid measurement of membrane resistance, capacitance, and access resistance.

@article{Donnelly1994ANM,
  title={A novel method for rapid measurement of membrane resistance, capacitance, and access resistance.},
  author={David F. Donnelly},
  journal={Biophysical journal},
  year={1994},
  volume={66 3 Pt 1},
  pages={873-7}
}
During patch clamp recordings, measurement of passive parameters such as access resistance (Ra), membrane resistance (Rm), and membrane capacitance (Cm) often provides useful information regarding physiological changes in the cell. In particular, an increase in capacitance may indicate vesicle fusion events as occurs during exocytosis. Rapid capacitance changes are usually measured with a phase-sensitive detector set to a phase angle that is independent of resistance changes. However, this… CONTINUE READING

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