A novel method for prognostic evaluation of childhood acute lymphoblastic leukemia

@article{Sinha1999ANM,
  title={A novel method for prognostic evaluation of childhood acute lymphoblastic leukemia},
  author={Dinesh Sinha and Chhabinath Mandal and D K Bhattacharya},
  journal={Leukemia},
  year={1999},
  volume={13},
  pages={309-312}
}
309 Survival from relapse was short despite intensive treatment, especially chemotherapy, given in these transplanted patients. CNS relapse probably emerged from resistant plasma cells which escaped the cytoreductive chemotherapy and conditioning regimen. In fact, high-dose melphalan, the main drug of inensive treatment in myeloma, does not cross the blood–brain barrier. Taken together, these observations suggest that neuro-meningeal prophylaxis including cranial radiotherapy should be part of… CONTINUE READING