A novel method for generation of signature networks as biomarkers from complex high throughput data.

@article{Nikolsky2005ANM,
  title={A novel method for generation of signature networks as biomarkers from complex high throughput data.},
  author={Yuri Nikolsky and Sean Ekins and Tatiana Nikolskaya and Andrej Bugrim},
  journal={Toxicology letters},
  year={2005},
  volume={158 1},
  pages={20-9}
}
Traditionally, gene signatures are statistically deduced from large gene expression and proteomics datasets and have been applied as an experimental molecular diagnostic technique that is sensitive to experimental design and statistical treatment. We have developed and applied the approach of "signature networks" which overcomes some of the drawbacks of clustering methods. We have demonstrated signature network assembly, functional analysis and logical operations on the networks that can be… CONTINUE READING

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