A novel method for automated assessment of megakaryocyte differentiation and proplatelet formation

  title={A novel method for automated assessment of megakaryocyte differentiation and proplatelet formation},
  author={Manuel Salzmann and Bastian Hoesel and Mildred Haase and Marion Mussbacher and Waltraud Cornelia Schrottmaier and Julia Barbara Kral-Pointner and Michaela Finsterbusch and Alexandra Mazharian and Alice Assinger and Johannes A. Schmid},
  pages={357 - 364}
Abstract Transfusion of platelet concentrates represents an important treatment for various bleeding complications. However, the short half-life and frequent contaminations with bacteria restrict the availability of platelet concentrates and raise a clear demand for platelets generated ex vivo. Therefore, in vitro platelet generation from megakaryocytes represents an important research topic. A vital step for this process represents accurate analysis of thrombopoiesis and proplatelet formation… 

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