A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes.

@article{Satoh2006ANM,
  title={A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes.},
  author={Kazuki Satoh and Mitsumi Hata and Seiji Takahara and Hidetoshi Tsuzaki and Hiroshi Yokota and Hiroyasu Akatsu and Takayuki Yamamoto and Kenji Kosaka and Tatsuo Yamada},
  journal={Brain research},
  year={2006},
  volume={1108 1},
  pages={19-27}
}
Beta-amyloid (Abeta) deposition and senile plaque-associated astrocytes are common neuropathological features of Alzheimer's disease (AD). Although the molecular mechanisms by which Abeta contributes to the progression of neuropathologic changes have not been entirely established, there is little doubt that the association of Abeta with astrocytes, the predominant cell type in brain, significantly influences exacerbation of the disease. In an effort to identify astrocyte-derived molecules that… CONTINUE READING
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