A novel mechanism underlying drug resistance in chronic epilepsy.

@article{Remy2003ANM,
  title={A novel mechanism underlying drug resistance in chronic epilepsy.},
  author={Stefan Remy and Siegrun Gabriel and Bernd W. Urban and Dirk Dietrich and Thomas Nicolas Lehmann and Christian Erich Elger and Uwe F Heinemann and Heinz Beck},
  journal={Annals of neurology},
  year={2003},
  volume={53 4},
  pages={
          469-79
        }
}
The development of resistance to pharmacological treatment is common to many human diseases. In chronic epilepsy, many patients develop resistance to anticonvulsant drug treatment during the course of their disease, with the underlying mechanisms remaining unclear. We have studied cellular mechanisms underlying drug resistance in resected hippocampal tissue from patients with temporal lobe epilepsy by comparing two groups of patients, the first displaying a clinical response to the… CONTINUE READING
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