A novel mechanism of retinoic acid resistance in acute promyelocytic leukemia cells through a defective pathway in telomerase regulation

@article{Pendino2002ANM,
  title={A novel mechanism of retinoic acid resistance in acute promyelocytic leukemia cells through a defective pathway in telomerase regulation},
  author={Fr{\'e}d{\'e}ric Pendino and Tewfik Sahraoui and Michel Lanotte and Evelyne S{\'e}gal-Bendirdjian},
  journal={Leukemia},
  year={2002},
  volume={16},
  pages={826-832}
}
Human telomerase, a cellular reverse transcriptase specifically activated in most malignant tumors and usually inactive in normal somatic cells, plays an important role in immortalization and tumorigenesis. Early reports have indicated that terminal differentiation of various cells is associated with a rapid inhibition of telomerase activity, preceded by a down-regulation of telomerase reverse transcriptase (hTERT) mRNA. Recently, we have shown that telomerase can be repressed by all-trans… CONTINUE READING
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