A novel mechanism of interaction between alpha-synuclein and biological membranes.

@article{Kim2006ANM,
  title={A novel mechanism of interaction between alpha-synuclein and biological membranes.},
  author={Yoon Suk Kim and Emmanuelle Laurine and W. S. Woods and Seung-Jae Lee},
  journal={Journal of molecular biology},
  year={2006},
  volume={360 2},
  pages={386-97}
}
Conformational abnormalities and aggregation of alpha-synuclein (alpha-syn) have been linked to the pathogenesis of Parkinson's (PD) and related diseases. It has been shown that alpha-syn can stably bind artificial phospholipid vesicles through alpha-helix formation in its N-terminal repeat region. However, little is known about the membrane interaction in cells. In the current study, we determined the membrane-binding properties of alpha-syn to biological membranes by using bi-functional… CONTINUE READING