A novel mechanism of glucocorticosteroid (GC) action in suppression of phospholipase A2 (PLA2) activity stimulated by Ca2+ ionophore A23187: induction of protein phosphatases.

@article{Zor1991ANM,
  title={A novel mechanism of glucocorticosteroid (GC) action in suppression of phospholipase A2 (PLA2) activity stimulated by Ca2+ ionophore A23187: induction of protein phosphatases.},
  author={Uriel Zor and E Her and Pierre G. Braquet and Ernst Ferber and Nachum Reiss},
  journal={Advances in prostaglandin, thromboxane, and leukotriene research},
  year={1991},
  volume={21A},
  pages={265-71}
}
The present article deals with the stimulation of membrane PLA2 induced by activated protein kinase C (PKC), and the effect of a deficiency in cellular PKC activity in reducing in PLA2 activity. The mode of glucocorticoid (GC) inhibition action in regulation of PLA2 activity, by enhancement of protein dephosphorylation in general, and PLA2 in particular, is… CONTINUE READING