A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

@inproceedings{AtkinSmith2015ANM,
  title={A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure},
  author={Georgia K. Atkin-Smith and Rochelle Tixeira and Stephanie Paone and S. Mathivanan and Christine C Collins and Michael Liem and Katharine J. Goodall and Kodi Ravichandran and Mark D Hulett and Ivan K H Poon},
  booktitle={Nature communications},
  year={2015}
}
Disassembly of apoptotic cells into smaller fragments (a form of extracellular vesicle called apoptotic bodies) can facilitate removal of apoptotic debris and intercellular communication. However, the mechanism underpinning this process is unclear. While observing monocytes undergoing apoptosis by time-lapse microscopy, we discovered a new type of membrane protrusion that resembles a 'beads-on-a-string' structure. Strikingly, the 'beads' are frequently sheared off the 'string' to form apoptotic… CONTINUE READING
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evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma

  • Y. S. Chen
  • 2013

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