A novel mechanism of action of chemically modified tetracyclines: inhibition of COX-2-mediated prostaglandin E2 production.

@article{Patel1999ANM,
  title={A novel mechanism of action of chemically modified tetracyclines: inhibition of COX-2-mediated prostaglandin E2 production.},
  author={Rajesh N. Patel and Mukundan G. Attur and Mandar Dave and Indravadan V. Patel and Steven A. Stuchin and Steven B. Abramson and Ashok R. Amin},
  journal={Journal of immunology},
  year={1999},
  volume={163 6},
  pages={3459-67}
}
Tetracyclines (doxycycline and minocycline) inhibit inducible NO synthase expression and augment cyclooxygenase (COX)-2 expression and PGE2 production. In contrast, chemically modified tetracyclines (CMTs), such as CMT-3 and -8 (but not CMT-1, -2, and -5), that lack antimicrobial activity, inhibit both NO and PGE2 production in LPS-stimulated murine macrophages, bovine chondrocytes, and human osteoarthritis-affected cartilage, which spontaneously produces NO and PGE2 in ex vivo conditions… CONTINUE READING
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