A novel mechanism of TGFbeta-induced actin reorganization mediated by Smad proteins and Rho GTPases.

@article{Vardouli2008ANM,
  title={A novel mechanism of TGFbeta-induced actin reorganization mediated by Smad proteins and Rho GTPases.},
  author={Lina Vardouli and Eleftheria Vasilaki and Elsa Papadimitriou and Dimitris Kardassis and Christos Stournaras},
  journal={The FEBS journal},
  year={2008},
  volume={275 16},
  pages={4074-87}
}
In previous studies, we have demonstrated that RhoA/B-dependent signaling regulates TGFbeta-induced rapid actin reorganization in Swiss 3T3 fibroblasts. Here we report that TGFbeta regulates long-term actin remodeling by increasing the steady-state mRNA levels of the RhoB gene in mouse Swiss 3T3 fibroblasts and human hepatoma HepG2 cells. We show that this regulation is specific for the RhoB gene and is facilitated by enhanced activity of the RhoB promoter. Adenovirus-mediated gene transfer of… CONTINUE READING

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