A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion.

@article{Mizukami1997ANM,
  title={A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion.},
  author={Yoichi Mizukami and Katsuji Yoshioka and Sachio Morimoto and Ken Yoshida},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 26},
  pages={16657-62}
}
Cytokines and various cellular stresses are known to activate c-Jun NH2-terminal kinase (JNK), which plays a role in conveying signals from the cytosol to the nucleus. Here we investigate the translocation and activation of JNK1 during ischemia and reperfusion in perfused rat heart. Ischemia induces the translocation of JNK1 from the cytosol fraction to the nuclear fraction in a time-dependent manner. Immunohistochemical observation also shows that JNK1 staining in the nucleus is enhanced after… CONTINUE READING

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