A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production.

@article{Kaku2014ANM,
  title={A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production.},
  author={Hiroaki Kaku and Kai Fan Cheng and Y. Al-abed and Thomas L. Rothstein},
  journal={Journal of immunology},
  year={2014},
  volume={193 12},
  pages={
          5904-13
        }
}
Immune suppression by regulatory T cells and regulatory B cells is a critical mechanism to limit excess inflammation and autoimmunity. IL-10 is considered the major mediator of B cell-induced immune suppression. We report a novel mechanism for immune suppression through adenosine generation by B cells. We identified a novel population of B cells that expresses CD73 as well as CD39, two ectoenzymes that together catalyze the extracellular dephosphorylation of adenine nucleotides to adenosine… CONTINUE READING
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