A novel mechanism for the transcriptional regulation of Wnt signaling in development.

@article{Vacik2011ANM,
  title={A novel mechanism for the transcriptional regulation of Wnt signaling in development.},
  author={Tomas Vacik and Jennifer L. Stubbs and Greg Lemke},
  journal={Genes & development},
  year={2011},
  volume={25 17},
  pages={
          1783-95
        }
}
Axial patterning of the embryonic brain requires a precise balance between canonical Wnt signaling, which dorsalizes the nervous system, and Sonic hedgehog (Shh), which ventralizes it. The ventral anterior homeobox (Vax) transcription factors are induced by Shh and ventralize the forebrain through a mechanism that is poorly understood. We therefore sought to delineate direct Vax target genes. Among these, we identify an extraordinarily conserved intronic region within the gene encoding Tcf7l2… CONTINUE READING

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