A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone.

Abstract

Specific inhibitors of hyaluronan (HA) biosynthesis can be valuable therapeutic agents to prevent cancer invasion and metastasis. We have found previously that 4-methylumbelliferone (MU) inhibits HA synthesis in human skin fibroblasts and in group C Streptococcus. In this paper, the inhibition mechanism in mammalian cells was investigated using rat 3Y1… (More)

Topics

10 Figures and Tables

Slides referencing similar topics