A novel mechanism for ribonuclease regulation: transfer-messenger RNA (tmRNA) and its associated protein SmpB regulate the stability of RNase R.

@article{Liang2010ANM,
  title={A novel mechanism for ribonuclease regulation: transfer-messenger RNA (tmRNA) and its associated protein SmpB regulate the stability of RNase R.},
  author={Wenxing Liang and Murray P. Deutscher},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 38},
  pages={29054-8}
}
The amount of RNase R, an important degradative exoribonuclease, increases 3-10-fold under a variety of stress conditions. This elevation is due to posttranslational regulation in which the highly unstable RNase R protein becomes stabilized during stress. Here we identify two components of the trans-translation machinery, transfer-messenger RNA (tmRNA) and SmpB, that are responsible for the short half-life of RNase R in exponential phase cells. The absence of either lengthens the half-life of… CONTINUE READING
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1344–1352 REPORT: Regulation of RNase R Stability 29058 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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