A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei.

@article{GraslKraupp2002ANM,
  title={A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei.},
  author={Bettina Grasl-Kraupp and Elisabeth Schausberger and Karin Hufnagl and Christopher Gerner and Alexandra Loew-Baselli and Walter Rossmanith and Wolfram Parzefall and Rolf Schulte-Hermann},
  journal={Hepatology},
  year={2002},
  volume={35 6},
  pages={1372-80}
}
Transforming growth factor (TGF) alpha, an important mediator of growth stimulation, is known to act via epidermal growth factor receptor (EGF-R) binding in the cell membrane. Here we show by immunohistology, 2-dimensional immunoblotting, and mass spectrometry of nuclear fractions that the pro-protein of wild-type TGF-alpha occurs in hepatocyte nuclei of human, rat, and mouse liver. Several findings show a close association between nuclear pro-TGF-alpha and DNA synthesis. (1) The number of pro… CONTINUE READING