A novel mechanism for inflammation-associated carcinogenesis; an important role of activation-induced cytidine deaminase (AID) in mutation induction

@article{Chiba2009ANM,
  title={A novel mechanism for inflammation-associated carcinogenesis; an important role of activation-induced cytidine deaminase (AID) in mutation induction},
  author={Tsutomu Chiba and Hiroyuki Marusawa},
  journal={Journal of Molecular Medicine},
  year={2009},
  volume={87},
  pages={1023-1027}
}
Inflammation is a risk for cancer development; however, its mechanism is unknown. Recent studies have revealed that activation-induced cytidine deaminase (AID), which plays essential roles in both class-switch recombination and somatic hypermutation of immunoglobulin gene in B lymphocytes, is aberrantly expressed in non-lymphoid cells not only by H.pylori… CONTINUE READING