A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity.

@article{Okada2004ANM,
  title={A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity.},
  author={Masayuki Okada and Souichi Adachi and Tsuyoshi Imai and Ken-ichiro Watanabe and Shin-ya Toyokuni and Masaki Ueno and Antonis S. Zervos and Guido Kroemer and Tatsutoshi Nakahata},
  journal={Blood},
  year={2004},
  volume={103 6},
  pages={2299-307}
}
Caspase-independent programmed cell death can exhibit either an apoptosis-like or a necrosis-like morphology. The ABL kinase inhibitor, imatinib mesylate, has been reported to induce apoptosis of BCR-ABL-positive cells in a caspase-dependent fashion. We investigated whether caspases alone were the mediators of imatinib mesylate-induced cell death. In contrast to previous reports, we found that a broad caspase inhibitor, zVAD-fmk, failed to prevent the death of imatinib mesylate-treated BCR-ABL… CONTINUE READING
48 Citations
71 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Similar Papers

Loading similar papers…