A novel mechanism for endothelial progenitor cells homing: The SDF-1/CXCR4-Rac pathway may regulate endothelial progenitor cells homing through cellular polarization.

@article{Shen2011ANM,
  title={A novel mechanism for endothelial progenitor cells homing: The SDF-1/CXCR4-Rac pathway may regulate endothelial progenitor cells homing through cellular polarization.},
  author={Li Shen and Yongxing Gao and Juying Qian and Aijun Sun and Junbo Ge},
  journal={Medical hypotheses},
  year={2011},
  volume={76 2},
  pages={256-8}
}
The term "homing" describes the migration of circulating stem/progenitor cells into a target tissue. Mobilization of endothelial progenitor cells (EPCs) and regulation of their homing to ischemic tissues has become a novel therapy for accelerating endothelial repair in ischemic heart disease. However, the mechanisms for EPCs' directional migration and homing remain uncertain. Migrating cells, including EPCs, are characterized by their cellular polarity and polarity change (polarization… CONTINUE READING
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