A novel mechanism for NETosis provides antimicrobial defense at the oral mucosa.

@article{Mohanty2015ANM,
  title={A novel mechanism for NETosis provides antimicrobial defense at the oral mucosa.},
  author={Tirthankar Mohanty and Jonathan Sj{\"o}gren and Fredrik Kahn and Anas H. A. Abu-Humaidan and Niels Fisker and Kristian Assing and Matthias M{\"o}rgelin and Anders A. Bengtsson and Niels Borregaard and Ole E S\orensen},
  journal={Blood},
  year={2015},
  volume={126 18},
  pages={2128-37}
}
Neutrophils are essential for host defense at the oral mucosa and neutropenia or functional neutrophil defects lead to disordered oral homeostasis. We found that neutrophils from the oral mucosa harvested from morning saliva had released neutrophil extracellular traps (undergone NETosis) in vivo. The NETosis was mediated through intracellular signals elicited by binding of sialyl Lewis(X) present on salival mucins to l-selectin on neutrophils. This led to rapid loss of nuclear membrane and… CONTINUE READING
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