A novel macromolecular prodrug concept exploiting endogenous serum albumin as a drug carrier for cancer chemotherapy.

@article{Kratz2000ANM,
  title={A novel macromolecular prodrug concept exploiting endogenous serum albumin as a drug carrier for cancer chemotherapy.},
  author={Felix Kratz and Ralph M{\"u}ller-Driver and Irmgard Hofmann and Joachim Drevs and Clemens Unger},
  journal={Journal of medicinal chemistry},
  year={2000},
  volume={43 7},
  pages={1253-6}
}
Introduction. Serum proteins are potential drug carriers of antineoplastic agents due to their accumulation in tumor tissue.1 Uptake of these proteins in solid tumors is mediated by a number of factors including an increased metabolic activity of tumors, an enhanced vascular permeability of tumor blood vessels for circulating macromolecules, and a lack of a functional lymphatic drainage system in tumor tissue.2 Recently, a number of acid-sensitive albumin and transferrin conjugates with… CONTINUE READING
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In vivo and in vitro efficacy of an acid-sensitive albumin conjugate of doxorubicin compared to the parent compound in murine renal cell carcinoma

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Synthesis and stability of four maleimide derivatives of the anticancer drug doxorubicin for the preparation of chemoimmunoconjugates

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Synthesis of new maleimide derivatives of daunorubicin and biological activity of acid-labile transferrin conjugates

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