A novel mGlu4 selective agonist LSP4-2022 increases behavioral despair in mouse models of antidepressant action

@article{Podkowa2015ANM,
  title={A novel mGlu4 selective agonist LSP4-2022 increases behavioral despair in mouse models of antidepressant action},
  author={Karolina Podkowa and Szymon Rzeźniczek and Marcin Marciniak and Francine C Acher and Agnieszka Pałucha-Poniewiera},
  journal={Neuropharmacology},
  year={2015},
  volume={97},
  pages={338-345}
}
Numerous data have indicated that metabotropic glutamate (mGlu) receptor ligands may be potentially useful as novel antidepressant drugs (ADs). The Group III mGlu receptor has not been explored much because of the limited access to selective ligands, but some behavioral studies have indicated that modulating group III mGlu receptors may result in benefits for the therapy of depression. Here, we investigated the potential antidepressant-like effects of a new mGlu4 selective orthosteric agonist… CONTINUE READING
BETA