A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration.

@article{Huang2007ANL,
  title={A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration.},
  author={Fei Huang and Dolly Mehta and Sanda A. Predescu and Kwang Sik Kim and Hazel Lum},
  journal={Endothelium : journal of endothelial cell research},
  year={2007},
  volume={14 1},
  pages={25-34}
}
Abundant evidence documents the highly proinflammatory actions of lysophosphatidylcholine (LPC). Further, LPC, found in high amounts in oxidized low-density lipoprotein (LDL), is implicated as an atherogenic factor. In endothelial cells, LPC impairs endothelial barrier function through GPR4, a novel receptor hypothesized to be sensitive to LPC and protons. The authors investigated the stimulation by LPC or low pH of GPR4 in human brain microvascular endothelial cells (HBMECs) and whether the… CONTINUE READING