A novel luciferin-based bright chemiluminescent probe for the detection of reactive oxygen species.

@article{Sekiya2009ANL,
  title={A novel luciferin-based bright chemiluminescent probe for the detection of reactive oxygen species.},
  author={Maki Sekiya and Keitaro Umezawa and Akemi Sato and Daniel Citterio and Koji Suzuki},
  journal={Chemical communications},
  year={2009},
  volume={21},
  pages={
          3047-9
        }
}
This communication reports the synthesis, chemiluminescence properties, and biological application of KEIO-BODIPY-imidazopyrazine (KBI), a yellow-green chemiluminescent probe for the detection of reactive oxygen species (ROS) generated from living cells. 
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Methods Citations
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50 Citations

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Citation Type

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TLDR
Experimental results demonstrate that PCLA-O2(•-) exhibits ultrahigh sensitivity at the picomole level, dramatically prolonged luminescence time, specificity, and excellent biocompatibility, which ensure that PCla-O 2 (•-) as a self-luminescing probe is an alternative in vivo imaging approach for ultralow level O2 (•-).
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