A novel long distance base-pairing interaction in human immunodeficiency virus type 1 RNA occludes the Gag start codon.

@article{Abbink2003ANL,
  title={A novel long distance base-pairing interaction in human immunodeficiency virus type 1 RNA occludes the Gag start codon.},
  author={Truus E. M. Abbink and Ben Berkhout},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 13},
  pages={11601-11}
}
The 5'-untranslated region (5'-UTR) is the most conserved part of the HIV-1 RNA genome, and it contains regulatory motifs that mediate various steps in the viral life cycle. Previous work showed that the 5'-terminal 290 nucleotides of HIV-1 RNA adopt two mutually exclusive secondary structures, long distance interaction (LDI) and branched multiple hairpin (BMH). BMH has multiple hairpins, including the dimer initiation signal (DIS) hairpin that mediates RNA dimerization. LDI contains a long… CONTINUE READING
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