A novel locus DFNA59 for autosomal dominant nonsyndromic hearing loss maps at chromosome 11p14.2–q12.3

@article{Chatterjee2008ANL,
  title={A novel locus DFNA59 for autosomal dominant nonsyndromic hearing loss maps at chromosome 11p14.2–q12.3},
  author={A. Chatterjee and R. Jalvi and Nishtha Pandey and R. Rangasayee and A. Anand},
  journal={Human Genetics},
  year={2008},
  volume={124},
  pages={669-675}
}
  • A. Chatterjee, R. Jalvi, +2 authors A. Anand
  • Published 2008
  • Biology, Medicine
  • Human Genetics
  • Autosomal dominant nonsyndromic hearing loss (ADNSHL) accounts for about one-fifth of hereditary hearing loss in humans. In the present study, we have analyzed a three-generation family with 14 of its members manifesting ADNSHL, using a genome-wide linkage mapping approach. We found a novel locus DFNA59 between the D11S929 and D11S480 markers in the chromosome location 11p14.2–q12.3. The highest two-point lod score of 5.72 at recombination fraction = 0 was obtained for D11S4152, D11S4154… CONTINUE READING
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