A novel locus (RP24) for X-linked retinitis pigmentosa maps to Xq26-27.

  title={A novel locus (RP24) for X-linked retinitis pigmentosa maps to Xq26-27.},
  author={Linn M Gieser and Ricardo Fujita and Harald H. H. G{\"o}ring and J{\"u}rg Ott and Dennis R. Hoffman and Artur V. Cideciyan and David G. Birch and Samuel G. Jacobson and Anand Swaroop},
  journal={American journal of human genetics},
  volume={63 5},
Two genetic loci, RP2 and RP3, for X-linked retinitis pigmentosa (XLRP) have been localized to Xp11.3-11.23 and Xp21.1, respectively. RP3 appears to account for 70% of XLRP families; however, mutations in the RPGR gene (isolated from the RP3 region) are identified in only 20% of affected families. Close location of XLRP loci at Xp and a lack of unambiguous clinical criteria do not permit assignment of genetic subtype in a majority of XLRP families; nonetheless, in some pedigrees, both RP2 and… CONTINUE READING
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Localization of a novel X-linked progressive cone dystrophy gene to Xq27: evidence for genetic heterogeneity

  • Bergen AAB, Pinckers AJLG
  • Am J Hum Genet
  • 1997

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