A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages.

@article{Shimada1998ANL,
  title={A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages.},
  author={Takuji Shimada and Misako Matsumoto and Yoichi Tatsumi and Akihisa Kanamaru and Shizuo Akira},
  journal={FEBS letters},
  year={1998},
  volume={425 3},
  pages={490-4}
}
To identify genes induced in activated macrophages, we screened a cDNA library prepared from the lipopolysaccharide (LPS)-treated cell line, RAW264, using the suppression subtractive hybridization technique. One of the clones isolated was dramatically induced by LPS in macrophages. The predicted protein sequence of this gene contains the domain unique to seven transmembrane receptors, and shows similarity with mouse C-C chemokine receptor 5 (CCR5). Therefore, we designated it LPS inducible C-C… CONTINUE READING

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