A novel line immunoassay based on recombinant virulence factors enables highly specific and sensitive serologic diagnosis of Helicobacter pylori infection.

@article{Formichella2013ANL,
  title={A novel line immunoassay based on recombinant virulence factors enables highly specific and sensitive serologic diagnosis of Helicobacter pylori infection.},
  author={Luca Formichella and Laura Romberg and Christian Bolz and Michael Vieth and Michael Geppert and Gereon Goettner and Christina Noelting and Dirk Walter and Wolfgang Schepp and Arne R. J. Schneider and K. Ulm and Petra Wolf and Dirk H Busch and Erwin Soutschek and Markus Gerhard},
  journal={Clinical and vaccine immunology : CVI},
  year={2013},
  volume={20 11},
  pages={1703-10}
}
Helicobacter pylori colonizes half of the world's population, and infection can lead to ulcers, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma. Serology is the only test applicable for large-scale, population-based screening, but current tests are hampered by a lack of sensitivity and/or specificity. Also, no serologic test allows the differentiation of type I and type II strains, which is important for predicting the clinical outcome. H. pylori virulence factors have… CONTINUE READING